反应详情

The product of Example 28C (350 mg, 0.79 mmol) was treated with HCl (Aldrich, 4 M in dioxane, 2 mL, 8 mmol) in EtOH (5 mL) at ambient temperature for 1 h. The mixture was concentrated and the title compound was purified by chromatography (SiO2, EtOAc:MeOH (v. 2% NH3.H2O), 50:50, Rf. 0.1) as white solid (250 mg, 93%). 1H NMR (300 MHz, MeOH-D4) δ 1.54-1.66 (m, 1H), 1.72-2.02 (m, 2H), 2.07-2.24 (m, 1H), 2.35-2.57 (m, 1H), 2.79-3.18 (m, 5H), 3.48-3.69 (m, 1H), 5.27-5.47 (m, 1H), 7.10 (d, J=8.8 Hz, 1H), 7.22 (d, J=9.5 Hz, 1H), 7.66 (s, 1H), 7.98 (d, J=9.2 Hz, 1H), 8.08 (dd, J=9.0, 2.2 Hz, 1H), 8.68 (d, J=2.4 Hz, 1H) ppm. MS (DCI/NH3): 342 (M+H)+.

1. concentrationThe mixture was concentrated
2. customthe title compound was purified by chromatography (SiO2, EtOAc:MeOH (v. 2% NH3.H2O), 50:50, Rf. 0.1) as white solid (250 mg, 93%)