HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1441485Generated: November 1, 2026
Hydrogen Bromide → 1,2,3,4-Tetrahydroisoquinolin-6-ol--hydrogen bromide (1/1)
https://huagongshe.com/reaction/1441485
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 2920335 | — |
| Product | 1,2,3,4-Tetrahydroisoquinolin-6-ol--hydrogen bromide (1/1) | HCID 13361799 | — |
Reaction Steps
6-Methoxy-1,2,3,4-tetrahydro-isoquinoline hydrochloride, prepared as in WO 2004/26305, (18.9 g, 94 mmol) in 48% aqueous hydrobromic acid was heated at 100° C. for 12 h and then cooled to 0° C. The solid was filtered off, washed with t-butyl methyl ether and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07655664B2 |
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| Source dataset | uspto-grants-2010_02 |
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| ORD ID | ord-4a8080546ced4774a28e117d61f088f1 |
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| Source note | uspto-grants-2010_02 |
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