反应详情

温度

100 °C

6-Methoxy-1,2,3,4-tetrahydro-isoquinoline hydrochloride, prepared as in WO 2004/26305, (18.9 g, 94 mmol) in 48% aqueous hydrobromic acid was heated at 100° C. for 12 h and then cooled to 0° C. The solid was filtered off, washed with t-butyl methyl ether and dried.

1. temperaturecooled to 0° C
2. filtrationThe solid was filtered off
3. washwashed with t-butyl methyl ether
4. customdried