Hydrochloric Acid → HCID 68543296, compound

HRID 1441681Notes

Reaction equation

HRID 1441681 reaction equation
O1CCCCC1[O:7][CH2:8][CH2:9][N:10]1[C:23]2[C:18](=[CH:19][C:20]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])=[CH:21][CH:22]=2)[C:12]2([CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:11]1=[O:31].Cl>CO>[OH:7][CH2:8][CH2:9][N:10]1[C:23]2[C:18](=[CH:19][C:20]([C:24]([O:26][C:27]([CH3:29])([CH3:28])[CH3:30])=[O:25])=[CH:21][CH:22]=2)[C:12]2([CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)[C:11]1=[O:31]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68539560HCID 68539560, compound

Product 1

HCID 68543296HCID 68543296, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(Tetrahydropyran-2-yl-oxy-ethyl)-5-tert-butoxycarbonyl-spiro[indoline-3,4′-piperidin]-2-one (0.021 g, 0.05 mmol) was dissolved in methanol (2 mL). To the reaction mixture was then added at room temperature aqueous 1.0N HCl (80 μL) and the reaction mixture was stirred for 30 minutes. The reaction mixture was then partitioned with aqueous Na2CO3 and ethyl acetate. The organic layer was washed with brine, dried with Na2SO4, filtered and the solvent evaporated in vacuo to yield the title compound as a solid.

Workup

  1. customThe reaction mixture was then partitioned with aqueous Na2CO3 and ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried with Na2SO4
  4. filtrationfiltered
  5. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-05c143276e394cc69205273ea0adc00b
Source dataset
uspto-grants-2010_02
Patent number
US07655670B2

Reaction notes

Loading…