反应详情

To a solution of 2-hydroxy-5-nitropyridine (600 mg, 4.28 mmol, 1 eq) in DMF (5 mL) was added cesium carbonate (1.67 g, 5.16 mmol, 1.2 eq), followed by methyl iodide (0.4 mL, 6.42 mmol, 1.5 eq). After stirring overnight, the reaction mixture was quenched with water and extracted with ethyl ether (5×20 mL). The ether was dried over Na2SO4 and concentrated under reduced pressure. The crude material was column chromatographed, eluting with 50% EtOAc/hexanes to give 450 mg of compound 50B.

1. customthe reaction mixture was quenched with water
2. extractionextracted with ethyl ether (5×20 mL)
3. dry with materialThe ether was dried over Na2SO4
4. concentrationconcentrated under reduced pressure
5. customchromatographed
6. washeluting with 50% EtOAc/hexanes