HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-5-nitro-2(1H)-pyridinone → 5-Amino-1-methyl-1,2-dihydropyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-5-nitro-2(1H)-pyridinone | HCID 295866 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Amino-1-methyl-1,2-dihydropyridin-2-one | HCID 10220005 | — |
Reaction Steps
A solution of compound 50B (200 mg, 1.298 mmol) and 10% Pd/C (˜5 mg) in MeOH and AcOH was stirred under H2 at 1 atmosphere for 30 minutes. The reaction solution was filtered through a pad of celite eluting with MeOH. The MeOH was removed under reduced pressure to give compound 50C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07655688B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-6bff92f6f0fa413cbb9b190ca49314cb |
| Source note | uspto-grants-2010_02 |