反应详情

温度

95 °C

A mixture of 4-diethylamino-3-(trifluoromethyl)-benzonitrile (1.21 g, 5 mmol), 12 mL of acetic acid and 8 mL of fuming hydrochloric acid (37%) is shaken for 20 hours at 95° C. After cooling, the reaction mixture is evaporated to dryness under reduced pressure. The solid residue is dissolved in a warm half-saturated aqueous sodium carbonate solution and the pH is adjusted to ˜5-6 by dropwise addition of 2M hydrochloric acid. The formed precipitate is filtered off, washed with water and dried in vacuo to yield a white solid.

1. temperatureAfter cooling
2. customthe reaction mixture is evaporated to dryness under reduced pressure
3. dissolutionThe solid residue is dissolved in a warm half-saturated aqueous sodium carbonate solution
4. additionthe pH is adjusted to ˜5-6 by dropwise addition of 2M hydrochloric acid
5. filtrationThe formed precipitate is filtered off
6. washwashed with water
7. customdried in vacuo
8. customto yield a white solid