Pyrrolidine → HCID 68679428, compound

HRID 1441735Notes

Reaction equation

HRID 1441735 reaction equation
Br[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1>>[N:14]1([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=2[C:10]([F:13])([F:12])[F:11])[CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 108006474-Bromo-3-(trifluoromethyl)benzonitrile

Product 1

HCID 68679428HCID 68679428, compound

Procedure

The title compound is prepared using an analogous method as described in Example 1.1, utilising 4-bromo-3-(trifluoromethyl)-benzonitrile and pyrrolidine (Fluka, Buchs, Switzerland), with a reaction temperature of 95° C.

Workup

  1. customwith a reaction temperature of 95° C.

Sources & evidence

ORD record
ord-c74b0bd19d634db39291226d180d886d
Source dataset
uspto-grants-2010_02
Patent number
US07655669B2

Reaction notes

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