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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1441736Generated: October 25, 2026

Morpholine → 4-Morpholino-3-(trifluoromethyl)benzonitrile

https://huagongshe.com/reaction/1441736

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
Reactant4-Bromo-3-(trifluoromethyl)benzonitrileHCID 10800647—
Product4-Morpholino-3-(trifluoromethyl)benzonitrileHCID 59556544—

Reaction Steps

The title compound is prepared using an analogous method as described in Example 1.1, utilising 4-bromo-3-(trifluoromethyl)-benzonitrile and morpholine (Fluka, Buchs, Switzerland), with a reaction temperature of 95° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07655669B2
Source datasetuspto-grants-2010_02
ORD IDord-7bd2feddec2d40edbf537f11ebe57a31
Source noteuspto-grants-2010_02