反应详情

温度

95 °C

A mixture of 4-(1H-imidazol-1-yl)-3-(trifluoromethyl)-benzonitrile (1.99 g, 8.4 mmol), 12 mL of acetic acid and 6 mL of 12M hydrochloric acid (37%) is shaken for 16 hours at 95° C. After cooling down the reaction mixture is evaporated under reduced pressure. The resulting residue is dissolved in water and the pH is adjusted to ˜5-6 by dropwise addition of 1M sodium hydroxide solution. The precipitate is filtered off, washed with water and dried in vacuo to afford the title compound as a solid.

1. temperatureAfter cooling down the reaction mixture
2. customis evaporated under reduced pressure
3. dissolutionThe resulting residue is dissolved in water
4. additionthe pH is adjusted to ˜5-6 by dropwise addition of 1M sodium hydroxide solution
5. filtrationThe precipitate is filtered off
6. washwashed with water
7. customdried in vacuo