反应详情

温度

95 °C

A mixture of 4-(2-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzonitrile (1.01 g, 4 mmol), 6 mL of acetic acid and 3 mL of 12M hydrochloric acid (37%) is shaken for 16 hours at 95° C. After cooling, the reaction mixture is evaporated to dryness under reduced pressure. The resulting residue is evaporated twice with toluene, dissolved in water and the pH is adjusted to ˜5-6 by dropwise addition of 1M sodium hydroxide solution. The aqueous phase is extracted twice with n-butanol and the organic phase evaporated to yield the title compound as a beige solid.

1. temperatureAfter cooling
2. customthe reaction mixture is evaporated to dryness under reduced pressure
3. customThe resulting residue is evaporated twice with toluene
4. dissolutiondissolved in water
5. additionthe pH is adjusted to ˜5-6 by dropwise addition of 1M sodium hydroxide solution
6. extractionThe aqueous phase is extracted twice with n-butanol
7. customthe organic phase evaporated