Imidazole → 3-(1H-imidazol-1-yl)-5-(trifluoromethyl)-benzonitrile

HRID 1441746Notes

Reaction equation

HRID 1441746 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)[C:5]#[N:6].[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[N:14]1([C:2]2[CH:3]=[C:4]([CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=2)[C:5]#[N:6])[CH:18]=[CH:17][N:16]=[CH:15]1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 5190373-Fluoro-5-(trifluoromethyl)benzonitrile

Product 1

HCID 686788663-(1H-imidazol-1-yl)-5-(trifluoromethyl)-benzonitrile

Procedure

The title compound is prepared using an analogous method as described in Example 1.1, utilising 3-fluoro-5-(trifluoromethyl)-benzonitrile (Lancaster Synthesis GmbH) and imidazole (Fluka, Buchs, Switzerland), with a reaction temperature of 110° C. for 24 hours.

Sources & evidence

ORD record
ord-d0dddc637c11435ba0650b48980c4ce9
Source dataset
uspto-grants-2010_02
Patent number
US07655669B2

Reaction notes

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