Morpholine → 3-morpholin-4-yl-5-(trifluoromethyl)benzonitrile

HRID 1441748Notes

Reaction equation

HRID 1441748 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)[C:5]#[N:6].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[N:14]1([C:2]2[CH:3]=[C:4]([CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=2)[C:5]#[N:6])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 5190373-Fluoro-5-(trifluoromethyl)benzonitrile

Product 1

HCID 111079463-morpholin-4-yl-5-(trifluoromethyl)benzonitrile

Procedure

The title compound is prepared using an analogous method as described in Example 1.1, utilising 3-fluoro-5-(trifluoromethyl)-benzonitrile (Lancaster Synthesis GmbH) and morpholine (Fluka, Buchs, Switzerland), with a reaction temperature of 105° C. for 14 hours.

Sources & evidence

ORD record
ord-f79f95c8c91f4548904236bddb20f433
Source dataset
uspto-grants-2010_02
Patent number
US07655669B2

Reaction notes

Loading…