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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1441748Generated: October 30, 2026

Morpholine → 3-morpholin-4-yl-5-(trifluoromethyl)benzonitrile

https://huagongshe.com/reaction/1441748

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
Reactant3-Fluoro-5-(trifluoromethyl)benzonitrileHCID 519037—
Product3-morpholin-4-yl-5-(trifluoromethyl)benzonitrileHCID 11107946—

Reaction Steps

The title compound is prepared using an analogous method as described in Example 1.1, utilising 3-fluoro-5-(trifluoromethyl)-benzonitrile (Lancaster Synthesis GmbH) and morpholine (Fluka, Buchs, Switzerland), with a reaction temperature of 105° C. for 14 hours.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07655669B2
Source datasetuspto-grants-2010_02
ORD IDord-f79f95c8c91f4548904236bddb20f433
Source noteuspto-grants-2010_02