Sodium Hydroxide → HCID 68678074, compound

HRID 1441753Notes

Reaction equation

HRID 1441753 reaction equation
Cl[C:2]1[CH:9]=[CH:8]C(C#N)=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[CH3:14][N:15]1[CH2:20][CH2:19][CH:18]([NH:21][CH3:22])[CH2:17][CH2:16]1.[OH-:23].[Na+].[O:25]1[CH2:30][CH2:29]OCC1>O>[CH3:22][N:21]([CH:18]1[CH2:19][CH2:20][N:15]([CH3:14])[CH2:16][CH2:17]1)[C:2]1[CH:9]=[CH:8][C:29]([C:30]([OH:25])=[O:23])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11]

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 5663231-Methyl-4-(methylamino)piperidineHCID 27364744-Chloro-3-(trifluoromethyl)benzonitrile

Product 1

HCID 68678074HCID 68678074, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound is prepared using an analogous method as described in Example 5.1, utilising 4-chloro-3-(trifluoromethyl)-benzonitrile (Lancaster Synthesis GmbH) and 1-methyl-4-(methylamino)-piperidine (Aldrich, Buchs, Switzerland). Subsequent hydrolysis of the nitrile is carried out with sodium hydroxide in a mixture of dioxane and water as described in Example 5.1.

Sources & evidence

ORD record
ord-d0e0e273da274075a5521fb1e4af63f5
Source dataset
uspto-grants-2010_02
Patent number
US07655669B2

Reaction notes

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