HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 68678074, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 1-Methyl-4-(methylamino)piperidine | HCID 566323 | — |
| Reactant | 4-Chloro-3-(trifluoromethyl)benzonitrile | HCID 2736474 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 68678074 | HCID 68678074 | — |
Reaction Steps
The title compound is prepared using an analogous method as described in Example 5.1, utilising 4-chloro-3-(trifluoromethyl)-benzonitrile (Lancaster Synthesis GmbH) and 1-methyl-4-(methylamino)-piperidine (Aldrich, Buchs, Switzerland). Subsequent hydrolysis of the nitrile is carried out with sodium hydroxide in a mixture of dioxane and water as described in Example 5.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07655669B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-d0e0e273da274075a5521fb1e4af63f5 |
| Source note | uspto-grants-2010_02 |