Sodium Hydroxide → HCID 22268711, compound

HRID 1441755Notes

Reaction equation

HRID 1441755 reaction equation
C[O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[C:6]([NH:14][CH2:15][CH3:16])[CH:5]=1.[OH-].[Na+]>C(O)C>[CH2:15]([NH:14][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:7]=1)[C:3]([OH:17])=[O:2])[CH3:16]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58679285HCID 58679285, compound

Product 1

HCID 22268711HCID 22268711, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 3-ethylamino-5-(trifluoromethyl)-benzoic acid methyl ester (1.38 g, 5.6 mmol), 5.5 mL 1M aqueous sodium hydroxide solution in 12 mL ethanol is shaken for 4 hours at 70° C. After cooling, the mixture is evaporated to dryness under reduced pressure. The resulting residue is dissolved in water, the pH adjusted to 5 with 1M hydrochloric acid. The precipitate is filtered off, washed with water and dried in vacuo to give the title compound.

Workup

  1. temperatureAfter cooling
  2. customthe mixture is evaporated to dryness under reduced pressure
  3. dissolutionThe resulting residue is dissolved in water
  4. filtrationThe precipitate is filtered off
  5. washwashed with water
  6. customdried in vacuo

Sources & evidence

ORD record
ord-d90dd562c5374722bdd54607754eb441
Source dataset
uspto-grants-2010_02
Patent number
US07655669B2

Reaction notes

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