Sodium Hydroxide → HCID 22268711, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-ethylamino-5-(trifluoromethyl)-benzoic acid methyl ester (1.38 g, 5.6 mmol), 5.5 mL 1M aqueous sodium hydroxide solution in 12 mL ethanol is shaken for 4 hours at 70° C. After cooling, the mixture is evaporated to dryness under reduced pressure. The resulting residue is dissolved in water, the pH adjusted to 5 with 1M hydrochloric acid. The precipitate is filtered off, washed with water and dried in vacuo to give the title compound.

Provenance & Evidence