反应详情

80 mL of dichloromethane was added to 10 g of pentaethyleneglycol and 10.7 g of silver oxide, and then 5.8 g of methanesulfonyl chloride dissolved in 16 ml of dichloromethane was added dropwise. After stirring the reaction solution at room temperature for 2 days, the solution was filtered with a celite, and then the filtrate was concentrated under reduced pressure. The residue was purified with silica gel column chromatography to obtain 7.8 g of the objective compound.

1. additionwas added dropwise
2. filtrationthe solution was filtered with a celite
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was purified with silica gel column chromatography