反应详情

10 g of pentaethyleneglycol was dissolved in a mixture of 100 mL of acetonitrile and 30 mL of pyridine, to which 11 g of trityl chloride were added at 0° C., and then the solution was stirred overnight at room temperature. The reaction solution was mixed with iced water and subjected to extraction with ethyl acetate, and then the organic layer washed with water and concentrated under reduced pressure after drying. The residue was purified with silica gel column chromatography to obtain 6 g of the objective compound.

1. additionwere added at 0° C.
2. extractionsubjected to extraction with ethyl acetate
3. washthe organic layer washed with water
4. concentrationconcentrated under reduced pressure
5. customafter drying
6. customThe residue was purified with silica gel column chromatography