Hydrochloric Acid → Anastrozole hydrochloride

HRID 1441920Notes

Reaction equation

HRID 1441920 reaction equation
[CH3:1][C:2]([C:6]1[CH:7]=[C:8]([CH2:17][N:18]2[N:22]=[CH:21][N:20]=[CH:19]2)[CH:9]=[C:10]([C:12]([C:15]#[N:16])([CH3:14])[CH3:13])[CH:11]=1)([C:4]#[N:5])[CH3:3].[ClH:23]>O>[CH3:3][C:2]([C:6]1[CH:7]=[C:8]([CH2:17][N:18]2[N:22]=[CH:21][N:20]=[CH:19]2)[CH:9]=[C:10]([C:12]([C:15]#[N:16])([CH3:13])[CH3:14])[CH:11]=1)([C:4]#[N:5])[CH3:1].[ClH:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 2187Anastrozole

Product 1

HCID 11580739Anastrozole hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.0 g of anastrozole base was suspended in 10 ml of water and 2.5 ml of 1:1 hydrochloric acid was added. The resulted solution was filtered and the filter was washed with 5 ml of distilled water. The filtrate was poured on a Petri dish and allowed to evaporate on air for 3 days. Well developed crystals of anastrozole hydrochloride were formed with m.p. 107.7 C (capillary) 0.6-0.7 g of the so formed crystals were dissolved in minimal amount of water (about 2 ml) and 20 ml of water was slowly added under stirring. Crystalline product precipitated during adding the water. The mixture was stirred for 30 minutes and allowed to stand for 2 days. The crystals were filtered, washed by 10 ml of water and dried on air.

Workup

  1. filtrationThe resulted solution was filtered
  2. washthe filter was washed with 5 ml of distilled water
  3. additionThe filtrate was poured on a Petri dish
  4. customto evaporate on air for 3 days

Sources & evidence

ORD record
ord-5db2784bebaa476eabb02f6efc7297cd
Source dataset
uspto-grants-2010_02
Patent number
US07655806B2

Reaction notes

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