Imidazole → HCID 58868990, compound

HRID 1441967Notes

Reaction equation

HRID 1441967 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([OH:17])[CH:16]=1)[CH:12]=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CN=C1.FC(F)(F)S(O[Si:29]([C:32]([CH3:35])([CH3:34])[CH3:33])([CH3:31])[CH3:30])(=O)=O>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([O:17][Si:29]([C:32]([CH3:35])([CH3:34])[CH3:33])([CH3:31])[CH3:30])[CH:16]=1)[CH:12]=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 795ImidazoleHCID 123564tert-Butyldimethylsilyl trifluoromethanesulphonateHCID 19995077HCID 19995077, compound

Product 1

HCID 58868990HCID 58868990, compound

Procedure

Preparation takes place in analogy to Example 11 from 2.8 g (12.3 mmol) of 3-(benzyloxy)-5-hydroxybenzaldehyde (Example 3J), 1.67 g (24.5 mmol) of imidazole and 3.57 g (13.5 mmol) of tert-butyldimethylsilyl trifluoromethanesulfonate.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-52d2efa22cf7469fa3f21ca752ab5b98
Source dataset
uspto-grants-2010_02
Patent number
US07655643B2

Reaction notes

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