反应详情

温度

70 °C

36 mg (0.55 mmol) of sodium azide are added to a solution of 218 mg (0.55 mmol) of (2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl methanesulfonate (Example Z7) in 15 ml of dimethylformamide and the mixture is stirred at 70° C. for 12 h. Most of the solvent is distilled off in vacuo, and the residue is diluted with ethyl acetate. The solution is washed several times with a saturated sodium bicarbonate solution, dried over magnesium sulfate and evaporated to dryness in vacuo. The product is reacted without further purification.

1. distillationMost of the solvent is distilled off in vacuo
2. additionthe residue is diluted with ethyl acetate
3. washThe solution is washed several times with a saturated sodium bicarbonate solution
4. dry with materialdried over magnesium sulfate
5. customevaporated to dryness in vacuo
6. customThe product is reacted without further purification