Benzyl 2-amino-2-methylpropanoate hydrochloride → Benzyl 2-amino-2-methylpropanoate

HRID 1442443Notes

Reaction equation

HRID 1442443 reaction equation
Cl.[NH2:2][C:3]([CH3:15])([CH3:14])[C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5]>C(OCC)(=O)C>[NH2:2][C:3]([CH3:15])([CH3:14])[C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5]

Participants

3

Reactant 1

HCID 21415531Benzyl 2-amino-2-methylpropanoate hydrochloride

Product 1

HCID 11116894Benzyl 2-amino-2-methylpropanoateYield 96.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Benzyl 2-amino-2-methylpropionate hydrochloride (1.48 g) was dissolved in ethyl acetate (60 mL) and a saturated aqueous sodium hydrogen carbonate solution (20 mL), and the organic layer was separated. The organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (1.2 g).

Workup

  1. customa saturated aqueous sodium hydrogen carbonate solution (20 mL), and the organic layer was separated
  2. washThe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-79df1b56083d4695b53e2b612188dd52
Source dataset
uspto-grants-2010_02
Patent number
US07655632B2

Reaction notes

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