HCID 59166707, compound → HCID 59166716, compound

HRID 1442687Notes

Reaction equation

HRID 1442687 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([C:13]([C:18]3[CH:23]=[CH:22][C:21]([O:24]CC4C=CC=CC=4)=[C:20]([CH3:32])[CH:19]=3)([CH2:16][CH3:17])[CH2:14][CH3:15])=[N:10][C:9]=2[CH:33]=1)=[O:4]>[Pd]>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([C:13]([CH2:16][CH3:17])([C:18]3[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([CH3:32])[CH:19]=3)[CH2:14][CH3:15])=[N:10][C:9]=2[CH:33]=1)=[O:4]

Participants

3

Reactant 1

HCID 59166707HCID 59166707, compound

Product 1

HCID 59166716HCID 59166716, compoundYield 80.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

2-[1-(4-Benzyloxy-3-methyl-phenyl)-1-ethyl-propyl]-benzooxazole-5-carboxylic acid methyl ester (3.28 g, 7.39 mmol) and Pd—C (300 mg, 10%) is hydrogenated analogous to Example 1, step F to give the title product (2.10 g, 80%). MS (ES) m/e: 354.2 (M+1), 352.2 (M−1).

Sources & evidence

ORD record
ord-3692db25ddb949cd84c55a53e046385d
Source dataset
uspto-grants-2010_02
Patent number
US07659296B2

Reaction notes

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