反应详情

温度

80 °C

H2O2 (30%, 34 mL, 0.33 mol) was added to a solution of N-(5-ethylpyridin-2-yl)pivalamide (22 g, 0.11 mol) in HOAc (200 mL). The mixture was stirred overnight at 80° C. The reaction mixture was poured into water and was extracted with EtOAc. The organics were washed with sat. Na2SO3 and NaHCO3 before being dried over MgSO4. The solvent was evaporated in vacuo to afford 5-ethyl-2-pivalamidopyridine 1-oxide (16 g, 67%), which was used for the next step without further purification.

1. extractionwas extracted with EtOAc
2. washThe organics were washed with sat. Na2SO3 and NaHCO3
3. dry with materialbefore being dried over MgSO4
4. customThe solvent was evaporated in vacuo