Thionyl Chloride → 1-(4-Methoxyphenyl)cyclopropane-1-carbonyl chloride
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([OH:14])=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.S(Cl)([Cl:17])=O>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([Cl:17])=[O:14])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
To 1-(4-methoxyphenyl)cyclopropanecarboxylic acid (4.07 g, 21.2 mmol) were added thionyl chloride (4.64 mL, 63.5 mmol) and DMF (64 mL). The mixture was heated at 50° C. for 45 minutes. The excess thionyl chloride was evaporated under reduced pressure and the resulting acid chloride was used without further purification.
Workup
- customThe excess thionyl chloride was evaporated under reduced pressure
- customthe resulting acid chloride was used without further purification
Sources & evidence
- ORD record
- ord-d98260a1186448418d801a5c285b092e
- Source dataset
- uspto-grants-2010_02
- Patent number
- US07659268B2
Reaction notes
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