Hydrochloric Acid → HCID 19875228, compound

HRID 1442873Notes

Reaction equation

HRID 1442873 reaction equation
[O-:1][C:2]#[N:3].[K+].Cl.[NH2:6][CH2:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=O.Cl>O>[C:10]1([C:8]2[CH:7]=[N:6][C:2](=[O:1])[N:3]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 2723597Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1)HCID 11378442Potassium cyanate

Product 1

HCID 19875228HCID 19875228, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

Potassium cyanate (2.00 g, 24.7 mmol) was added in portions, over 15 min, to a stirred solution of 2-aminoacetophenone hydrochloride (3.85 g, 22.4 mmol) in water (130 mL) at 70° C., while the pH of the solution was maintained at pH 1 to 3 by addition of conc. hydrochloric acid. The reaction mixture was stirred at 70° C. for 4 h, then allowed to cool to ambient temperature and stood for 18 h. The title compound was isolated by filtration. MS: m/z=161 (M+1).

Workup

  1. temperatureto cool to ambient temperature
  2. waitstood for 18 h

Sources & evidence

ORD record
ord-5465f94fa6e04f25a6ddfac204c6f4a8
Source dataset
uspto-grants-2010_02
Patent number
US07659300B2

Reaction notes

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