反应详情

To a solution of 6.3 g (27.5 mmol) of methyl-4-chloro-5-methoxycarbonyl-nicotinate in 100 ml of THF is added 6.48 ml (35 mmol) of a 5.4 m solution of sodium methoxide in methanol. The mixture is stirred for 10 minutes and evaporated. 100 ml of a 0.25M aqueous HCl is added to the residue. The solution is made basic with K2CO3 and extracted with ethyl acetate. The organic phase is dried and evaporated to give an oil which crystallised on cooling. There is obtained 6.2 g (quantitative yield) of a solid (M+1=226).

1. customevaporated
2. addition100 ml of a 0.25M aqueous HCl is added to the residue
3. extractionextracted with ethyl acetate
4. customThe organic phase is dried
5. customevaporated
6. customto give an oil which
7. customcrystallised
8. temperatureon cooling