HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Phenyl-2,8-diazaspiro[4.5]decan-1-one dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 2-(tert-butylsulfinyl)-1-oxo-3-phenyl-2,8-diazaspiro[4.5]decane-8-carboxylate | HCID 68540347 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Phenyl-2,8-diazaspiro[4.5]decan-1-one dihydrochloride | HCID 68544563 | — |
Reaction Steps
To a solution of tert-butyl 2-(tert-butylsulfinyl)-1-oxo-3-phenyl-2,8-diazaspiro[4.5]decane-8-carboxylate (21 mg, 0.048 mmol) in methanol (4 mL) was added 4N HCl in dioxane (4 mL). After 24 h the reaction was concentrated give the title compound). MS: m/z=231.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07659264B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-c0711ab5f6e9480483c9b538bf7d272b |
| Source note | uspto-grants-2010_02 |