Hydrochloric Acid → 3-Phenyl-2,8-diazaspiro[4.5]decan-1-one dihydrochloride

HRID 1442906Notes

Reaction equation

HRID 1442906 reaction equation
C(S([N:7]1[CH:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:10][C:9]2([CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)[C:8]1=[O:30])=O)(C)(C)C.[ClH:31]>CO.O1CCOCC1>[ClH:31].[ClH:31].[C:12]1([CH:11]2[CH2:10][C:9]3([CH2:18][CH2:19][NH:20][CH2:21][CH2:22]3)[C:8](=[O:30])[NH:7]2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68540347Tert-butyl 2-(tert-butylsulfinyl)-1-oxo-3-phenyl-2,8-diazaspiro[4.5]decane-8-carboxylate

Product 1

HCID 685445633-Phenyl-2,8-diazaspiro[4.5]decan-1-one dihydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 2-(tert-butylsulfinyl)-1-oxo-3-phenyl-2,8-diazaspiro[4.5]decane-8-carboxylate (21 mg, 0.048 mmol) in methanol (4 mL) was added 4N HCl in dioxane (4 mL). After 24 h the reaction was concentrated give the title compound). MS: m/z=231.1 (M+1).

Workup

  1. concentrationAfter 24 h the reaction was concentrated

Sources & evidence

ORD record
ord-c0711ab5f6e9480483c9b538bf7d272b
Source dataset
uspto-grants-2010_02
Patent number
US07659264B2

Reaction notes

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