HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-phenyl-1,3,8-Triazaspiro[4.5]dec-1-en-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-oxo-2-phenyl-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate | HCID 59165778 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-phenyl-1,3,8-Triazaspiro[4.5]dec-1-en-4-one | HCID 21102147 | — |
Reaction Steps
To a solution of tert-butyl 4-oxo-2-phenyl-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate (45 mg, 0.137 mmol) in dichloromethane (5 mL) was added trifluoroacetic acid (2 mL). After 2 h the reaction was concentrated to give the title compound. MS: m/z=230.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07659264B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-857c583605a841b19ec2f6ac5d5ea748 |
| Source note | uspto-grants-2010_02 |