Trifluoroacetic acid → 2-phenyl-1,3,8-Triazaspiro[4.5]dec-1-en-4-one

HRID 1442914Notes

Reaction equation

HRID 1442914 reaction equation
[O:1]=[C:2]1[C:6]2([CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[N:5]=[C:4]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[NH:3]1.FC(F)(F)C(O)=O>ClCCl>[C:19]1([C:4]2[NH:3][C:2](=[O:1])[C:6]3([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]3)[N:5]=2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59165778Tert-butyl 4-oxo-2-phenyl-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate

Product 1

HCID 211021472-phenyl-1,3,8-Triazaspiro[4.5]dec-1-en-4-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-oxo-2-phenyl-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate (45 mg, 0.137 mmol) in dichloromethane (5 mL) was added trifluoroacetic acid (2 mL). After 2 h the reaction was concentrated to give the title compound. MS: m/z=230.1 (M+1).

Workup

  1. concentrationAfter 2 h the reaction was concentrated

Sources & evidence

ORD record
ord-857c583605a841b19ec2f6ac5d5ea748
Source dataset
uspto-grants-2010_02
Patent number
US07659264B2

Reaction notes

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