(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester → HCID 59166749, compound

HRID 1442966Notes

Reaction equation

HRID 1442966 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([OH:10])[CH2:7][N:6]1[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])=[O:4].[O:18]1[C:22]2[CH:23]=[C:24](O)[CH:25]=[CH:26][C:21]=2[CH2:20][CH2:19]1>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@H:8]([O:10][C:24]2[CH:25]=[CH:26][C:21]3[CH2:20][CH2:19][O:18][C:22]=3[CH:23]=2)[CH2:7][N:6]1[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])=[O:4]

Participants

3

Reactant 2

HCID 2734883(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl esterHCID 122365402,3-Dihydro-1-benzofuran-6-ol

Product 1

HCID 59166749HCID 59166749, compoundYield 41.6%

Procedure

The title compound was prepared from (2S,4R)-4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl-ester 2-methyl ester and 2,3-dihydro-benzofuran-6-ol by the method of Preparation 14 in 41.6% yield as a white solid.

Sources & evidence

ORD record
ord-77b981c7f77e49ad89ba8da0e5d6ee7c
Source dataset
uspto-grants-2010_02
Patent number
US07659305B2

Reaction notes

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