反应详情

温度

75 °C

Methanol (6.5 ml) and potassium tert-butoxide (18 g) were added sequentially, each in one portion, to a mixture of N-(3-chloro-4-fluorophenyl)-5,7-difluoroquinazolin-4-amine (13.8 g) in THF (270 ml) at room temperature under a nitrogen atmosphere. The mixture was heated at 75° C. for 18 hours 30 minutes and then cooled to room temperature and concentrated in vacuo to leave a brown solid. The solid was cooled to 0° C. and cold water was added and then the precipitate was filtered and dried to leave N-(3-chloro-4-fluorophenyl)-5,7-dimethoxyquinazolin-4-amine as a light brown solid (10.4 g, 69%); Mass spectrum MH+ 334.

1. temperaturecooled to room temperature
2. concentrationconcentrated in vacuo
3. customto leave a brown solid
4. temperatureThe solid was cooled to 0° C.
5. filtrationthe precipitate was filtered
6. customdried