HCID 59716934, compound → HCID 51664402, compound

HRID 1443052Notes

Reaction equation

HRID 1443052 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C@@H:15]2[CH2:20][CH2:19][CH2:18][CH2:17][N:16]2[CH3:21])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C1COCC1.[Pd]>[CH3:21][N:16]1[CH2:17][CH2:18][CH2:19][CH2:20][C@H:15]1[CH2:14][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 59716934HCID 59716934, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 51664402HCID 51664402, compoundYield 50%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (S)-1-benzyl-4-[(1-methylpiperidin-2-yl)methyl]piperazine 0.87 g (3.03 mmol) in THF (40 ml) was added 10% Pd/C 0.4 g and exposed to 1 atm hydrogen overnight. The reaction mixture was filtered. The filtrate was concentrated 0.3 g of desired product in 50% yield.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationThe filtrate was concentrated 0.3 g of desired product in 50% yield

Sources & evidence

ORD record
ord-4b14df2c1fc14e9586dfb3be2e43cbd2
Source dataset
uspto-grants-2010_02
Patent number
US07659395B2

Reaction notes

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