3-Bromopyridine → HCID 68544020, compound

HRID 1443071Notes

Reaction equation

HRID 1443071 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH:7]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)[OH:8])[CH2:2]1.BrC1C=NC=CC=1.[F:22][C:23]([F:33])([F:32])[O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1O>>[N:11]1[CH:12]=[CH:13][CH:14]=[C:9]([C@H:7]([O:8][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[O:24][C:23]([F:22])([F:33])[F:32])[C@@H:3]2[O:4][CH2:5][CH2:6][NH:1][CH2:2]2)[CH:10]=1

Participants

4

Reactant 3

HCID 122863-BromopyridineHCID 27772992-(Trifluoromethoxy)phenolHCID 68542861HCID 68542861, compound

Product 1

HCID 68544020HCID 68544020, compound

Procedure

(R)-2-[(S)-Pyridin-3-yl-(2-trifluoromethoxy-phenoxy)-methyl]-morpholine was synthesized via morpholin-2-yl-pyridin-3-yl-methanol from 3-bromopyridine and 2-trifluoromethoxyphenol according to general procedure C and was isolated as a gummy oil. MS (APCI): 355 [M+H]+.

Workup

  1. customwas isolated as a gummy oil

Sources & evidence

ORD record
ord-b724271b13ac4b1f8b180813c7ae4741
Source dataset
uspto-grants-2010_02
Patent number
US07659394B2

Reaction notes

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