2-Bromopyridine → HCID 68539132, compound

HRID 1443072Notes

Reaction equation

HRID 1443072 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH:7]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)[OH:8])[CH2:2]1.BrC1C=CC=CN=1.[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1O>>[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[O:8][C@@H:7]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[C@@H:3]1[O:4][CH2:5][CH2:6][NH:1][CH2:2]1

Participants

4

Reactant 3

HCID 79732-BromopyridineHCID 1230512,4-DifluorophenolHCID 68542861HCID 68542861, compound

Product 1

HCID 68539132HCID 68539132, compound

Procedure

(R)-2-[(S)-(2-,4-Difluoro-phenoxy)-pyridin-3-yl-methyl]-morpholine was synthesized via morpholin-2-yl-pyridin-3-yl-methanol from 2-bromopyridine and 2,4-difluorophenol according to general procedure C and was isolated as a gummy oil. MS (APCI): 307 [M+H]+.

Workup

  1. customwas isolated as a gummy oil

Sources & evidence

ORD record
ord-3792e1e7baf34b80b6dc7f17e9ade057
Source dataset
uspto-grants-2010_02
Patent number
US07659394B2

Reaction notes

Loading…