(3,5-Difluorophenyl)boronic acid → [7-(3,5-Difluoro-phenyl)-2-methyl-thiazolo[4,5-c]pyridin-4-yl]-(2-methyl-thiazol-4-yl)-amine

HRID 1443086Notes

Reaction equation

HRID 1443086 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([CH3:11])[S:10][C:6]=2[C:5](I)=[CH:4][N:3]=1.[F:13][C:14]1[CH:15]=[C:16](B(O)O)[CH:17]=[C:18]([F:20])[CH:19]=1.[NH2:24][C:25]1[N:26]=[C:27]([CH3:30])[S:28][CH:29]=1>>[F:13][C:14]1[CH:15]=[C:16]([C:5]2[C:6]3[S:10][C:9]([CH3:11])=[N:8][C:7]=3[C:2]([NH:24][C:25]3[N:26]=[C:27]([CH3:30])[S:28][CH:29]=3)=[N:3][CH:4]=2)[CH:17]=[C:18]([F:20])[CH:19]=1

Participants

4

Reactant 3

HCID 2734338(3,5-Difluorophenyl)boronic acidHCID 147727002-Methyl-1,3-thiazol-4-amineHCID 768504784-Chloro-7-iodo-2-methylthiazolo[4,5-c]pyridine

Product 1

HCID 16660739[7-(3,5-Difluoro-phenyl)-2-methyl-thiazolo[4,5-c]pyridin-4-yl]-(2-methyl-thiazol-4-yl)-amine

Procedure

The title compound, MS: m/e=375.1 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-7-iodo-2-methyl-thiazolo[4,5-c]pyridine (Example B), 3,5-difluorophenylboronic acid and 4-amino-2-methylthiazole (Example C).

Sources & evidence

ORD record
ord-3b3c4da2007c483ea3be14169ea6eb36
Source dataset
uspto-grants-2010_02
Patent number
US07659401B2

Reaction notes

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