HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3,5-Difluorophenyl)boronic acid → [7-(3,5-Difluoro-phenyl)-2-methyl-thiazolo[4,5-c]pyridin-4-yl]-(2-methyl-thiazol-4-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3,5-Difluorophenyl)boronic acid | HCID 2734338 | — |
| Reactant | 2-Methyl-1,3-thiazol-4-amine | HCID 14772700 | — |
| Reactant | 4-Chloro-7-iodo-2-methylthiazolo[4,5-c]pyridine | HCID 76850478 | — |
| Product | [7-(3,5-Difluoro-phenyl)-2-methyl-thiazolo[4,5-c]pyridin-4-yl]-(2-methyl-thiazol-4-yl)-amine | HCID 16660739 | — |
Reaction Steps
The title compound, MS: m/e=375.1 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-7-iodo-2-methyl-thiazolo[4,5-c]pyridine (Example B), 3,5-difluorophenylboronic acid and 4-amino-2-methylthiazole (Example C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07659401B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-3b3c4da2007c483ea3be14169ea6eb36 |
| Source note | uspto-grants-2010_02 |