2-Methylpyrimidin-4-amine → [7-(5-Fluoro-pyridin-3-yl)-2-methyl-thiazolo[4,5-c]pyridin-4-yl]-(2-methyl-pyrimidin-4-yl)-amine

HRID 1443088Notes

Reaction equation

HRID 1443088 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([CH3:11])[S:10][C:6]=2[C:5](I)=[CH:4][N:3]=1.[F:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18](B(O)O)[CH:19]=1.[NH2:23][C:24]1[CH:29]=[CH:28][N:27]=[C:26]([CH3:30])[N:25]=1>>[F:13][C:14]1[CH:19]=[C:18]([C:5]2[C:6]3[S:10][C:9]([CH3:11])=[N:8][C:7]=3[C:2]([NH:23][C:24]3[CH:29]=[CH:28][N:27]=[C:26]([CH3:30])[N:25]=3)=[N:3][CH:4]=2)[CH:17]=[N:16][CH:15]=1

Participants

4

Reactant 3

HCID 2957632-Methylpyrimidin-4-amineHCID 44717403(5-Fluoropyridin-3-yl)boronic acidHCID 768504784-Chloro-7-iodo-2-methylthiazolo[4,5-c]pyridine

Product 1

HCID 16660900[7-(5-Fluoro-pyridin-3-yl)-2-methyl-thiazolo[4,5-c]pyridin-4-yl]-(2-methyl-pyrimidin-4-yl)-amine

Procedure

The title compound, MS: m/e=353.2 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-7-iodo-2-methyl-thiazolo[4,5-c]pyridine (Example B), 3-fluoro-5-pyridineboronic acid and 4-amino-2-methylpyrimidine.

Sources & evidence

ORD record
ord-d1daa7d699b54b35adeabf5231f08384
Source dataset
uspto-grants-2010_02
Patent number
US07659401B2

Reaction notes

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