HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpyrimidin-4-amine → [7-(5-Fluoro-pyridin-3-yl)-2-methyl-thiazolo[4,5-c]pyridin-4-yl]-(2-methyl-pyrimidin-4-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpyrimidin-4-amine | HCID 295763 | — |
| Reactant | (5-Fluoropyridin-3-yl)boronic acid | HCID 44717403 | — |
| Reactant | 4-Chloro-7-iodo-2-methylthiazolo[4,5-c]pyridine | HCID 76850478 | — |
| Product | [7-(5-Fluoro-pyridin-3-yl)-2-methyl-thiazolo[4,5-c]pyridin-4-yl]-(2-methyl-pyrimidin-4-yl)-amine | HCID 16660900 | — |
Reaction Steps
The title compound, MS: m/e=353.2 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-7-iodo-2-methyl-thiazolo[4,5-c]pyridine (Example B), 3-fluoro-5-pyridineboronic acid and 4-amino-2-methylpyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07659401B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-d1daa7d699b54b35adeabf5231f08384 |
| Source note | uspto-grants-2010_02 |