4-Amino-2-methylpyridine → (2-Methyl-pyridin-4-yl)-(2-methyl-7-pyrimidin-5-yl-thiazolo[4,5-c]pyridin-4-yl)-amine

HRID 1443089Notes

Reaction equation

HRID 1443089 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([CH3:11])[S:10][C:6]=2[C:5](I)=[CH:4][N:3]=1.[N:13]1[CH:18]=[C:17](B(O)O)[CH:16]=[N:15][CH:14]=1.[CH3:22][C:23]1[CH:28]=[C:27]([NH2:29])[CH:26]=[CH:25][N:24]=1>>[CH3:22][C:23]1[CH:28]=[C:27]([NH:29][C:2]2[C:7]3[N:8]=[C:9]([CH3:11])[S:10][C:6]=3[C:5]([C:17]3[CH:18]=[N:13][CH:14]=[N:15][CH:16]=3)=[CH:4][N:3]=2)[CH:26]=[CH:25][N:24]=1

Participants

4

Reactant 3

HCID 7286704-Amino-2-methylpyridineHCID 2795193(Pyrimidin-5-yl)boronic acidHCID 768504784-Chloro-7-iodo-2-methylthiazolo[4,5-c]pyridine

Product 1

HCID 16660906(2-Methyl-pyridin-4-yl)-(2-methyl-7-pyrimidin-5-yl-thiazolo[4,5-c]pyridin-4-yl)-amine

Procedure

The title compound, MS: m/e=335.2 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-7-iodo-2-methyl-thiazolo[4,5-c]pyridine (Example B), 5-pyrimidineboronic acid and 2-methyl-4-aminopyridine.

Sources & evidence

ORD record
ord-acfb0f6e10ac44f5a0da6eb9788b3d12
Source dataset
uspto-grants-2010_02
Patent number
US07659401B2

Reaction notes

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