(Pyrimidin-5-yl)boronic acid → (2-Methyl-7-pyrimidin-5-yl-thiazolo[4,5-c]pyridin-4-yl)-(2-methyl-thiazol-4-yl)-amine

HRID 1443090Notes

Reaction equation

HRID 1443090 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([CH3:11])[S:10][C:6]=2[C:5](I)=[CH:4][N:3]=1.[N:13]1[CH:18]=[C:17](B(O)O)[CH:16]=[N:15][CH:14]=1.[NH2:22][C:23]1[N:24]=[C:25]([CH3:28])[S:26][CH:27]=1>>[CH3:11][C:9]1[S:10][C:6]2[C:5]([C:17]3[CH:18]=[N:13][CH:14]=[N:15][CH:16]=3)=[CH:4][N:3]=[C:2]([NH:22][C:23]3[N:24]=[C:25]([CH3:28])[S:26][CH:27]=3)[C:7]=2[N:8]=1

Participants

4

Reactant 3

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 147727002-Methyl-1,3-thiazol-4-amineHCID 768504784-Chloro-7-iodo-2-methylthiazolo[4,5-c]pyridine

Product 1

HCID 16661049(2-Methyl-7-pyrimidin-5-yl-thiazolo[4,5-c]pyridin-4-yl)-(2-methyl-thiazol-4-yl)-amine

Procedure

The title compound, MS: m/e=341.0 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-7-iodo-2-methyl-thiazolo[4,5-c]pyridine (Example B), 5-pyrimidineboronic acid and 4-amino-2-methylthiazole (Example C).

Sources & evidence

ORD record
ord-7b0dd737598448688297391ae7b3eeda
Source dataset
uspto-grants-2010_02
Patent number
US07659401B2

Reaction notes

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