4-Amino-2-methylpyridine → HCID 16661050, compound

HRID 1443091Notes

Reaction equation

HRID 1443091 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([CH3:11])[S:10][C:6]=2[C:5](I)=[CH:4][N:3]=1.[Cl:13][C:14]1[CH:19]=[C:18](B(O)O)[CH:17]=[CH:16][N:15]=1.[CH3:23][C:24]1[CH:29]=[C:28]([NH2:30])[CH:27]=[CH:26][N:25]=1>>[Cl:13][C:14]1[CH:19]=[C:18]([C:5]2[C:6]3[S:10][C:9]([CH3:11])=[N:8][C:7]=3[C:2]([NH:30][C:28]3[CH:27]=[CH:26][N:25]=[C:24]([CH3:23])[CH:29]=3)=[N:3][CH:4]=2)[CH:17]=[CH:16][N:15]=1

Participants

4

Reactant 3

HCID 7286704-Amino-2-methylpyridineHCID 51515952-Chloropyridine-4-boronic acidHCID 768504784-Chloro-7-iodo-2-methylthiazolo[4,5-c]pyridine

Product 1

HCID 16661050HCID 16661050, compound

Procedure

The title compound, MS: m/e=368.1 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-7-iodo-2-methyl-thiazolo[4,5-c]pyridine (Example B), 2-chloropyridin-4-boronic acid and 2-methyl-4-aminopyridine.

Sources & evidence

ORD record
ord-fd33fd40d0be4b959fd51d969d4ba41a
Source dataset
uspto-grants-2010_02
Patent number
US07659401B2

Reaction notes

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