2-Amino-5-methylpyridine → HCID 16660902, compound

HRID 1443098Notes

Reaction equation

HRID 1443098 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([CH3:11])[S:10][C:6]=2[C:5](I)=[CH:4][N:3]=1.[F:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18](B(O)O)[CH:19]=1.[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][N:25]=1>>[F:13][C:14]1[CH:19]=[C:18]([C:5]2[C:6]3[S:10][C:9]([CH3:11])=[N:8][C:7]=3[C:2]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][N:25]=3)=[N:3][CH:4]=2)[CH:17]=[N:16][CH:15]=1

Participants

4

Reactant 3

HCID 153482-Amino-5-methylpyridineHCID 44717403(5-Fluoropyridin-3-yl)boronic acidHCID 768504784-Chloro-7-iodo-2-methylthiazolo[4,5-c]pyridine

Product 1

HCID 16660902HCID 16660902, compound

Procedure

The title compound, MS: m/e=352.2 (M+H+), was prepared in accordance with the general method of example 2, step 1 and step 2 from 4-chloro-7-iodo-2-methyl-thiazolo[4,5-c]pyridine (Example B), 3-fluoro-5-pyridineboronic acid and 2-amino-5-methylpyridine.

Sources & evidence

ORD record
ord-0cd829ad3fff4f22a46a588dab7136aa
Source dataset
uspto-grants-2010_02
Patent number
US07659401B2

Reaction notes

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