Sodium Hydroxide → HCID 178526806, compound
Reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[N+:9]([O-:11])=[O:10].[OH-].[Na+]>Br>[N+:9]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:3]=1[OH:2])([O-:11])=[O:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 5 °C
Procedure
4-Methoxy-3-nitropyridine (25.0 g, 162 mmol) in 220 ml conc. hydrobromic acid (48%) was refluxed at 100° C. for 16 hrs. The reaction mixture was cooled, poured into ice water and neutralized with 155 ml conc. NaOH (32%). The suspension was stirred for 10 min. at 5° C. and filtered. The solid was washed with water and dried at 50° C. and <30 mbar for 1 hour. The desired product was obtained as a light yellow solid (20.2 g, 89%).
Workup
- temperatureThe reaction mixture was cooled
- filtrationfiltered
- washThe solid was washed with water
- customdried at 50° C.
- wait<30 mbar for 1 hour
Sources & evidence
- ORD record
- ord-7dcc2ad240cb4fa2be18133ec7d8a11d
- Source dataset
- uspto-grants-2010_02
- Patent number
- US07659401B2
Reaction notes
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