反应详情

2-Methyl-thiazolo[4,5-c]pyridine (2.3 g, 15.3 mmol) was dissolved in 150 ml chloroform and 3-chloroperoxybenzoic acid (4.15 g, 16.8 mmol) was added. The reaction mixture was stirred at ambient temperature for 1 hour and then evaporated. The residue was purified by flash chromatography on silica gel (dichloromethane/methanol 100:0->90:10 gradient). The desired product was obtained as a white solid (2.1 g, 83%), MS: m/e=167.2 (M+H+).

1. customevaporated
2. customThe residue was purified by flash chromatography on silica gel (dichloromethane/methanol 100:0->90:10 gradient)