反应详情

2-Methyl-thiazolo[4,5-c]pyridine 5-oxide (230 mg, 1.38 mmol) was refluxed 2 hrs in 4 ml of phosphoryl chloride. The reaction mixture was evaporated and extracted with ethyl acetate and saturated sodium bicarbonate-solution. The organic extracts were dried with sodium sulfate, filtered and evaporated. The residue was purified by flash chromatography on silica gel (heptane/ethyl acetate 90:10->0:100 gradient). The desired product was obtained as a light yellow solid (180 mg, 70%), MS: m/e=185.1 (M+H+).

1. customThe reaction mixture was evaporated
2. extractionextracted with ethyl acetate and saturated sodium bicarbonate-solution
3. dry with materialThe organic extracts were dried with sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe residue was purified by flash chromatography on silica gel (heptane/ethyl acetate 90:10->0:100 gradient)