反应详情

2M Na2CO3-solution (64 ml, 127 mmol), H2O2 (30%, 43.3 ml, 424 mmol) and 45 ml water were placed and a solution of 5-(2,2-dimethoxy-ethyl)-2-methyl-thiazole-4-carbonitrile (4.5 g, 21 mmol) in 45 ml acetone was added dropwise at room temperature. The white suspension was stirred for 2 hrs. Acetone was evaporated and the aqueous residue was extracted three times with ethyl acetate. The organic extracts were dried with sodium sulfate, filtered and evaporated. The crude product (4.8 g, 98%) was used without any further purification for the next step.

1. customAcetone was evaporated
2. extractionthe aqueous residue was extracted three times with ethyl acetate
3. dry with materialThe organic extracts were dried with sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe crude product (4.8 g, 98%) was used without any further purification for the next step